| 摘要 |
<p>A method for efficiently preparing pioglitazone is provided to obtain the pioglitazone effective as a prophylatic and therapeutic agent of diabetes from a novel intermediate of pioglitazone by removing a protection group therefrom. The method for preparing pioglitazone represented by the formula(1) comprises a step of performing a deprotection reaction on a compound represented by the formula(2) in the presence of an acid catalyst at a temperature of 20-100 deg.C. In the formula(2), Z is a protecting group of thiazolidine-2,4-dione selected from the group consisting of 4-nitrobenzyl, beta-propionitril or trytyl(-C(Ph)3). The compound of the formula(2) is prepared by performing Mitsunobu reaction(SN2) on a compound represented by the formula(3) and a compound represented by the formula(4) using diethyl azodicarboxylate(DEAD) and triphenylphosphine(PPh3).</p> |
