| 摘要 |
The present invention provides both a method and means for regulating IkappaBalpha degradation, NFkappaB activity, and NFkappaB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IkappaBalpha and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with IkappaBalpha is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of IkappaBalpha, a decrease of NFkappaB activity, and a down-regulation of NFkappaB-dependent expression.
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