发明名称 |
METHODS FOR SHP1 MEDIATED NEUROPROTECTION |
摘要 |
The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.
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申请公布号 |
US2007065885(A1) |
申请公布日期 |
2007.03.22 |
申请号 |
US20060530234 |
申请日期 |
2006.09.08 |
申请人 |
RENZI MICHAEL;THIRUMALAI NAVNEETH;JOLLIFFE LINDA;FARRELL FRANCIS X |
发明人 |
RENZI MICHAEL;THIRUMALAI NAVNEETH;JOLLIFFE LINDA;FARRELL FRANCIS X. |
分类号 |
G01N33/567;A61K31/00;A61K31/381;A61K31/426;A61K31/427;A61K38/18;C12Q1/44;G01N33/53;G01N33/573 |
主分类号 |
G01N33/567 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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