摘要 |
A process for preparation of Methyl-(+)-(S)-alpha-(2-chlorophenyl) -6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester or salts thereof [clopidogrel or salts thereof of Formula (I)] having higher chiral purity and products thereof is provided. A process for purification of the compound prepared is also provided to enhance its efficacy by enhancing its optical rotation and chiral purity. In Formula (I), R is selected from a group comprising alkyl, alkoxy, hydroxy, amine etc., and R<SUB>1</SUB> is selected from the group comprising C<SUB>1-4</SUB> alkyl, C<SUB>1-4</SUB> alkoxy, hydroxy, nitro & halogen. The particular salt of interest of the present invention is the hydrogen sulfate of compound of the Formula (I), wherein R and R<SUB>1</SUB> are -OCH<SUB>3</SUB> and chloro-group at position 2 respectively. |
申请人 |
RPG LIFE SCIENCES LIMITED;SRIVASTAVA, ANITA, RANJAN;PAWAR, PRASHANT, PANDURANG;POOJARI, KRISHNA, ANAND;PATIL, PRAVIN, CHAITRAM;DALVI, RAJIV, RAMCHANDRA |
发明人 |
SRIVASTAVA, ANITA, RANJAN;PAWAR, PRASHANT, PANDURANG;POOJARI, KRISHNA, ANAND;PATIL, PRAVIN, CHAITRAM;DALVI, RAJIV, RAMCHANDRA |