摘要 |
This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II) or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R<SUP>3</SUP>, R<SUP>4</SUP> and R<SUP>5</SUP> are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias. |
申请人 |
CARDIOME PHARMA CORP.;ROTH, CAROL, J.;JUNG, GRACE;YEE, JAMES GEE KEN;CHOU, DOUG TA HUNG;PLOUVIER, BERTRAND, M., C. |
发明人 |
JUNG, GRACE;YEE, JAMES GEE KEN;CHOU, DOUG TA HUNG;PLOUVIER, BERTRAND, M., C. |