Novel indole derivatives with an improved antipsychotic activity

摘要

The present invention relates to a novel indol derivative according to Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables R^{1, R2}, R³, R⁴, R⁵, p, a¹-a²a³-a⁴, Z¹-Z², X and Y are defined as in claim 1 . Said derivative exhibit a binding affinity towards dopamine receptors, in particular towards dopamine D₂, D₃ and D₄ receptors, with selective serotonin reuptake inhibition properties and acting as 5-HT_1A agonists or partial agonists. The invention also relates to pharmaceutical compositions comprising the compounds according to the invention, the use thereof for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic disorders, most in particular schizophrenia and processes for their production.