发明名称 |
Production of recombinant AAV using adenovirus comprising AAV rep/cap genes |
摘要 |
This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA inert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 promoter of rep is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogeneous preparation and compositions of rAAV.
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申请公布号 |
US2007065412(A1) |
申请公布日期 |
2007.03.22 |
申请号 |
US20060509855 |
申请日期 |
2006.08.25 |
申请人 |
CHEN HAIFENG;KURTZMAN GARY |
发明人 |
CHEN HAIFENG;KURTZMAN GARY |
分类号 |
A61K48/00;C12N15/861 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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