发明名称 |
INTEGRASE FUSION PROTEINS AND THEIR USE WITH INTEGRATING GENE THERAPY. |
摘要 |
<p>In a method of targeting integration of a transgene comprising retrovirus-like DNA into a eukaryotic genome, the genome is cleared by an endonuclease and the transgene is introduced at the site of cleavage, wherein the endonuclease is specific to a site in an abundant rDNA locus and is fused to an integrase that mediates the introduction of the transgene. The fusion protein may be new.</p> |
申请公布号 |
MXPA06008000(A) |
申请公布日期 |
2007.03.21 |
申请号 |
MX2006PA08000 |
申请日期 |
2005.01.14 |
申请人 |
ARK THERAPEUTICS LTD. |
发明人 |
MERVI AHLROTH;DIANA SCHENKWEIN;KARL AIRENNE;SEPPO YLA-HERTTUALA;OLLI LAITINEN |
分类号 |
A61K38/00;C07K14/16;C12N9/22;C12N15/62;C12N15/867;C12N15/90 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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