摘要 |
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 μM), and dimer and multimeric constructs comprising these polypeptides. |
申请人 |
DYAX CORP.;BRACCO INTERNATIONAL B.V. |
发明人 |
SATO, AARON, K.;SEXTON, DANIEL, J.;DRANSFIELD, DANIEL, T.;LADNER, ROBERT, C.;ARBOGAST, CHRISTOPHE;BUSSAT, PHILIPPE;FAN, HONG;KHURANA, SUDHA;LINDER, KAREN, E.;MARINELLI, EDMUND, R.;NANJAPPAN, PALANIAPPA;NUNN, ADRIAN;PILLAI, RADHAKRISHNA;POCHON, SIBYLLE;RAMALINGAM, KONDAREDDIAR;SHRIVASTAVA, AJAY;SONG, BO;SWENSON, ROLF E.;VON WRONSKI, MATHEW A. |