| 摘要 |
<p>Use of a plant-derived tanning agent (A), or its derivative, as active agent in a composition for prevention or treatment of chemotherapy-induced diarrhea (CiD). ACTIVITY : Antidiarrhea. No details of tests for antidiarrhea activity are given. MECHANISM OF ACTION : (A) causes reversible crosslinking of collagen structures in the intestine, forming a protective membrane and this (a) reduces stress on the epithelial cells and (b) allows regeneration of underlying tissue; also its astringent properties reduce electrolyte loss (caused by conversion of tight junctions to leaky junctions).</p> |
