TRICYCLIC COMPOUNDS AND THEIR USE AS MGLUR1 ANTAGONISTS.

摘要

In its many embodiments, the present invention provides tricyclic compoundsof Formula (I) (wherein J1-J4, X, and R1-R5are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists,particularly as selective metabotropic glutamate receptor 1 antagonists,pharmaceutical compositions containing the compounds, and methods of treatmentusing the compounds and compositions to treat diseases associated with metabotropicglutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety,urinary incontinence and neurodegenerative diseases such Alzheimer'sdisease.