| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: described is method of obtaining N-(2-nitroxyethyl)nicotinamide (nicorandyl) of formula by nitrating intermediate N-(2-hydroxyethyl)nicotinamide, which, in its turn, is obtained by interaction of ethylnicotinate with excess of monoethanolamine, differing by the following: reaction is carried out in ethanol and output of N-(2-hydroxyethyl)nicotinamide is brought up to quantitative. ^ EFFECT: increase of nicorandyl output from 83-84% to 94% and reduction of wastes amount. ^ 1 cl, 2 ex |
