| 摘要 |
<p>Crystalline form IV of agomelatine ((I); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide) is new. Crystalline form IV of agomelatine having powder X-ray diffraction diagram, measured using a diffractometer (copper anticathode) and expressed in terms of inter-planar distance d (17.524-3.190 A[deg]), Bragg's angle 2 theta (5.04-27.95 degree), intensity and relative intensity (6-100 percentage with respect to the most intense), is new. Independent claims are included for: (1) the preparation of (I); and (2) a composition comprising (I) and, inert and non-toxic carriers. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen.; Sedative; Muscular-Gen.; Immunomodulator; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen.; Contraceptive; Cytostatic. MECHANISM OF ACTION : Melatoninergic receptor agonist.</p> |
