Antibacterial agents

摘要

Compounds of formula (I) have antibacterial activity; wherein Q represents a radical of formula -N(OH)CH(-O) or formula -C(-O)NH(OH); Y represents -C(-O)-, -C(-S)-, -S(-O)-, or -SO₂-; R₁ represents hydrogen, C₁-C₆ alkyl or C₁-C₆ alkyl substituted by one or more halogen atoms, or, except when Q is a radical of formula -N(OH)CH(-O), a hydroxy, C₁-C₆ alkoxy, C₁-C₆ alkenyloxy, halogen, amino, C₁-C₆ alkylamino, or di-(C₁-C₆ alkyl)amino group; R₂ represents a substituted or unsubstituted C₁-C₆ alkyl, C₁-C₃ alkyl-O-C₁-C₃ alkyl, C₁-C₃ alkyl-S-C₁-C₃ alkyl, cycloalkyl(C₁-C₃ alkyl)-, aryl(C₁-C₃alkyl)-, heterocyclyl(C₁-C₃ alkyl)-, or R¹R²N-C₁-C₃ alkyl group wherein R¹ represents hydrogen or C₁-C₃ alkyl and R² represents C₁-C₃ alkyl, or R¹R²N-represents a cyclic amino group; R₃ and R₄ taken together with the nitrogen atoms to which they are respectively attached form a saturated heterocyclic ring of from 4 to 7 ring atoms, which may be fused to a second carbocyclic or heterocyclic ring, either of which rings may optionally be substituted; and A represents a primary, secondary or tertiary amino group or a group -R₅, -OR₅, wherein R₅ is a substituted or unsubstituted C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, cycloalkyl, aryl, heterocyclyl, C₁-C₃ alkyl-O-C₁-C₃alkyl, C₁-C₃ alkyl-S-C₁-C₃ alkyl, cycloalkyl(C₁-C₃ alkyl)-, heterocyclic(C₁-C₃ alkyl, aryl(C₁-C₃ alkyl)-or R¹R²N-C₁-C₃ alkyl group wherein R¹ represents hydrogen or C₁-C₃ alkyl and R² represents C₁-C₃ alkyl, or R¹R²N-represents a cyclic amino group