| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel substituted derivatives of C-cyclohexylmethylamine of the general formula (I): in their free form or physiologically compatible salts possessing analgesic effect. In the general formula (I) A means hydrogen atom (H) or unsubstituted phenyl; R1 means saturated or unsaturated, branched or linear mono- or multisubstituted or unsubstituted (C1-C10)-alkyl or (C3-C10)-cycloalkyl, phenyl, naphthyl, furyl, thiophenyl or naphthyl added through unsaturated (C2-C3)-alkyl either through (C1-C3)-alkylene or ethynyl, (C3-C10)-cycloalkyl added through unsaturated (C2-C3)-alkyl or through (C1-C3)-alkylene or ethynyl, or thiophenyl added through unsaturated (C2-C3)-alkyl, either through (C1-C3)-alkylene or ethynyl, respectively, unsubstituted or mono- either multi-substituted with residues chosen independently of one another from a group comprising fluorine (F), chlorine (Cl), bromine (Br), iodine (J) atom, -OR18, -SR18, silyl, unsubstituted or mono- either multi-substituted alkyl wherein substituted of substitutes of (C1-C10)-alkyl are similar or different and are chosen from the group comprising F, Cl, and Br and wherein R18 represents H or saturated or unsaturated, branched or linear, unsubstituted (C1-C10)-alkyl; R2 and R3 mean independently of one another branches or linear saturated unsubstituted (C1-C10)-alkyl, or R2 and R3 form in common the group -CH2CH2NR6CH2CH2 wherein R6 means branched or linear (C1-C10)-alkyl; X in the formula (I) in correspondence with the subformula (1a): of the formula (I) represents or wherein B represents -OH, -OR7, H, F or Cl wherein R7 means mono- or multi-substituted phenyl added through (C1-C3)-alkylene wherein substitutes of phenyl are chosen from F and Cl and others. Also, invention relates to a pharmaceutical composition based on compounds of the invention and to using these compounds. Proposed compounds can be used in treatment of pain being firstly in case of nephropathic or chronic pains. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. ^ 17 cl, 421 ex |
