Modulators of peroxisome proliferator activated receptors

摘要

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH₂- or -CH₂CH₂-; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R₁ and W, R₁ is (CH₂)_n-CH(OR₂)-(CH₂)_mE₁, -(CH)-C(OR₂)-(CH₂)_mE, -(CH₂)_n-CH(Y)-(CH₂)_mE or (CH)-C(Y)-(CH₂)_mE; wherein E is COOR₃, C₁-C₃ alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C₁-C₆ alkyl, haloalkyl and aryl-C₀-4-alkyl; R₂ is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, -COR₄, -COOR₄, -CONR₅R₆, -C(S)R₄, -C(S)OR₄ or C(S)NR₅R₆, R₃ is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O-, CH₂-, -CH₂CH₂- or CH-CH- and is bonded to a carbon atom in Phenyl Ring A that is ortho to R₁. R₄-R₆ are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2