| 摘要 |
New salts according to the invention are presented, which comprise salts of olanzapine and carboxylic acids selected from the group consisting of: maleic acid, fumaric acid, phtalic acid, benzoic acid, salicylic acid or acetylsalicylic acid, of olanzapine to acid ratio of 1: 1, 1:2 or other. New salts of olanzapine and monoesters of dicarboxylic acids obtained in reaction of olanzapine with anhydrides selected from the group consisting of maleic anhydride, phtalic anhydride and succinic anhydride are presented. The method of synthesis of new olanzapine salts according to the invention comprises carrying out the reaction of olanzapine in organic solvents with carboxylic acids selected from the group consisting of: maleic acid, fumaric acid, phtalic acid, succinic acid, benzoic acid, salicylic acid and acetylsalicylic acid. The method of synthesis of new olanzapine salts according to the invention comprises carrying out the reaction of olanzapine with an anhydride of a dicarboxylic acid selected from the group consisting of maleic anhydride, phtalic anhydride and succinic anhydride in the presence of alcohol in organic solvents. |
