| 摘要 |
The invention provides pharmaceutical compositions for topical administration in treating vaginal infections, e.g. vaginitis. Such compositions comprise: W at least one triazole compound active against Candida albicans, preferably at least one such compound which is additionally active against one or more non- albicans Candida species, and (ii) at least one additional anti-vaginitis medicament, preferably an anti-fungal, anti-protozoal and/or anti-bacterial agent. Preferred compositions include as active agents is terconazole in combination with tinidazole and/or tioconazole. In a further aspect the compositions in accordance with the invention also include a bioadhesive agent, e.g. a mucoadhesive, to promote adhesion to the vaginal mucosa. The use of a bioadhesive may also provide for controlled, e.g. rapid and/or delayed (sustained), release of the active agents. |
