POLYALKYLENE GLYCOL DERIVATIVES OF IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE
摘要
Novel epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors, pharmaceutical compositions including same and their use in the treatment of EGFR-TK related diseases or disorders are disclosed. Novel radiolabeled EGFR-TK irreversible inhibitors as their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are further disclosed. The disclosed EGFR-TK irreversible inhibitors comprise a polyalkylene glycol moiety and are characterized by improved solubility, biostability and bioavailability.
申请公布号
WO2007029251(A2)
申请公布日期
2007.03.15
申请号
WO2006IL01038
申请日期
2006.09.06
申请人
T.K. SIGNAL LTD.;MISHANI, EYAL;DISSOKI, SAMAR;ABOURBEH, GALITH;LEVITZKI, ALEXANDER
发明人
MISHANI, EYAL;DISSOKI, SAMAR;ABOURBEH, GALITH;LEVITZKI, ALEXANDER