A buffering system having a pKa which may be selected based on the environment in which the solution is designed to be used. Solutions containing the buffering system according to the present invention include borate-polyol complexes as the primary buffering agents, and may include one or more of the following: an aqueous liquid medium; an antimicrobial component; a surfactant component; a viscosity-inducing component; and/or a tonicity component. The borate-polyol buffering system may be formulated to have a lower pKa than traditional systems.
申请公布号
WO2006110482(A3)
申请公布日期
2007.03.15
申请号
WO2006US12886
申请日期
2006.04.06
申请人
ADVANCED MEDICAL OPTICS, INC.;YU, ZHI-JIAN;CRONER, DIANE, M.