METHODS FOR TREATING IMMUNE MEDIATED NEUROLOGICAL DISEASES

摘要

Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation, Immune complexed IgG to IgG F.gamma.R binding, and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding. Such compounds may have therapeutic u se in treating amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), a nd Alzheimer's disease (AD).