PROCESS FOR PRODUCTION OF 3-ALKENYLCEPHEM COMPOUNDS

摘要

A process for the production of 7-amino-3- [(E/Z)-2- (4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of formula (1) and alkali metal salts thereof which have enhanced contents of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3- cephem-4-carboxylic acid of formula (2) and alkali metal salts thereof, characterized by adding a high-porous polymer and/or activated carbon to an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5- yl)vinyl]-3-cephem -4-carboxylic acid of formula (1) to treat the solution with the high-porous polymer and/or the activated carbon. ® KIPO & WIPO 2007