MODIFICATION OF DOUBLE-STRANDED RIBONUCLEIC ACID MOLECULES
摘要
<p>A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5'-methyl-pyrimidine and/or at least one 2'-O-methyl ribonucleotide, and a method of improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA.</p>
申请公布号
WO2007030167(A1)
申请公布日期
2007.03.15
申请号
WO2006US20627
申请日期
2006.05.25
申请人
NASTECH PHARMACEUTICAL COMPANY INC.;QUAY, STEVEN, C.;CUI, KUNYUAN;JOHNSON, PAUL, HICKOK;CHEN, LISHAN;AHMADIAN, MOHAMMAD
发明人
QUAY, STEVEN, C.;CUI, KUNYUAN;JOHNSON, PAUL, HICKOK;CHEN, LISHAN;AHMADIAN, MOHAMMAD
