COMPOUNDS FOR COVALENT BINDING TO MD-2 AND EFFECT ON THE IMMUNE RESPONSE

摘要

The invention presents the applications of compounds, which contain a combination of a hydrophobic group with a group, which is reactive with the cysteine residue for the binding to protein MD-2. The compounds are covalently linked to MD-2, which is either free or in the complex with other molecules. The said compounds replace or prevent binding of other ligands, especially bacterial endotoxin (lipopolysaccharide-LPS), which can otherwise lead towards unwanted activation of the immune response and acute or chronic inflammatory diseases.