发明名称 |
ADJUVANT COMPOSITION COMPRISING ALUMINIUM PHOSPHATE AND 3D-MPL |
摘要 |
An immunogenic composition comprising: (i) an antigen; (ii) an aluminum phosphate adjuvant; and (iii) a 3-O-deacylated monophosphoryl lipid A adjuvant. Components (ii) and (iii) can also be used as a separate adjuvant system. Various features of the compositions are disclosed, including that at least 50 % of the 3-O-deacylated monophosphoryl lipid A adjuvant should be adsorbed to the aluminum phosphate adjuvant. The adjuvant mixture is particularly useful with hepatitis B virus surface antigen. |
申请公布号 |
WO2006087563(A3) |
申请公布日期 |
2007.03.15 |
申请号 |
WO2006GB00557 |
申请日期 |
2006.02.16 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC.;O'HAGAN, DEREK |
发明人 |
O'HAGAN, DEREK |
分类号 |
A61K39/39;A61P31/00 |
主分类号 |
A61K39/39 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|