DICARBONIC ACID DERIVATIVES, METASTASIS INHIBITORS AND AGENTS INCREASING CHEMOTHERAPEUTIC ACTIVITY OF ANTI-TUMOR PREPARATIONS, METHOD FOR ENHANCING THE CYTOSTATIC EFFICIENCY AND METASTASIS PROCESS INHIBITING METHOD

摘要

The invention relates to dicarbonic acid derivatives, in particular to monooximides and dicarbonic acid dioxydiamides which are physiologically active substances and can be used in the form of low-toxic and non-toxic agents for enhancing anti-tumor and anti-metastasis effects of known cytostatics (cyclophosphane and cisplatin) in cytostatic chemotherapy of tumors. The aim of said invention is to extend the variety of agents acting on a live organism for enhancing anti-tumor and anti-metastasis effects of known cytostatics. Said aim is attained by the properties of monooximides and dicarbonic acid dioxydiamides. The invention is characterised by the use of dicarbonic acid derivatives in the form of agents for enhancing anti-tumor and anti-metastasis effects of cytostatics of formulas given in a description. The inventive compounds can be used in medicine in the form of low-toxic means for enhancing anti-tumor and anti-metastasis effects of known cytostatics and for reducing the cytostatic therapeutic dose by four times. The use of the inventive compounds in combination with cisplatin minimum doses makes it possible to totally inhibit the metastasis process of experimental melanoma B-16. In addition, the use of minimum doses of the inventive compounds in combination with the cytostatic minimum doses (when said preparations are individually inefficient ) makes it possible to attain a high therapeutic effect for treating (the survival of test group of animals having leukaemia P-338 is equal to 100%)