| 摘要 |
PROBLEM TO BE SOLVED: To provide a new 5-HT<SB>1B</SB>antagonist composition for depression, anxiety, and a cognitive function. SOLUTION: This pharmaceutical composition contains a benzyl(idene)-lactam derivative expressed by formula I [R<SP>1</SP>is a group depicted by G<SP>1</SP>or G<SP>2</SP>in formula (α)], its pharmaceutically acceptable salt, or its optical isomer with at least one active substance selected from (a) a selective serotonin reuptake inhibitory substance (SSRI), (b) an alpha-2-delta (A2D) ligand, and (c) a corticotropin releasing factor (CRF) antagonist and optionally further contains a pharmaceutically acceptable carrier. COPYRIGHT: (C)2007,JPO&INPIT
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