A FLUORESCENT PHOTOPROBE FOR THE IMAGING OF ENDOTHELIN RECEPTORS
摘要
<p>The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R<SUB>2</SUB> is an alkoxy group and one of R<SUB>1</SUB> and R<SUB>3</SUB> represents an alkoxy group and the other represents a group of the formula: (OCH<SUB>2</SUB>CH<SUB>2</SUB>)<SUB>n</SUB>-NH-X, wherein n is an integer of 1 to 100 and X represents a fluorescent dye and tautomers thereof. Furthermore, the present invention relates to a diagnostic composition comprising the compounds of the invention. The present invention also relates to the use of the compounds of the invention for the preparation of a diagnostic composition for the the diagnosis of cancer, the evaluation of cancer biology and/or monitoring of anticancer therapy. In a further aspect, the present invention relates to kits comprising the compounds of the invention.</p>
申请公布号
WO2007028599(A2)
申请公布日期
2007.03.15
申请号
WO2006EP08701
申请日期
2006.09.06
申请人
UNIVERSITAETSKLINIKUM MUENSTER;BREMER, CHRISTOPH;HOELTKE, CARSTEN;KOPKA, KLAUS;SCHAEFERS, MICHAEL
发明人
BREMER, CHRISTOPH;HOELTKE, CARSTEN;KOPKA, KLAUS;SCHAEFERS, MICHAEL
