| 摘要 |
A process for preparing 8-substituted oxy- 5-((R)-2-halo-l-hydroxy-ethyl)-(1 H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(alpha -haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8- (substituted oxy)-5-((R)-2-halo-l-hydroxy-ethyl)-(1H) -quinolin-2-one, said chiral agent having a formula (I) or (II), wherein M, L, X, R1, R2 and R3 have the meanings as indicated in the specification. ® KIPO & WIPO 2007
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