发明名称 |
Generation of xenogeneic antibodies |
摘要 |
The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci. |
申请公布号 |
EP0710719(B1) |
申请公布日期 |
2007.03.14 |
申请号 |
EP19950115451 |
申请日期 |
1991.01.11 |
申请人 |
AMGEN FREMONT INC. |
发明人 |
KUCHERLAPATI, RAJU;JAKOBOVITS, AYA |
分类号 |
A01K67/027;C12N15/00;A61K38/00;A61K39/00;A61K39/395;C07K14/00;C07K14/435;C07K16/00;C07K16/12;C07K16/24;C07K16/28;C07K16/46;C07K19/00;C12N;C12N5/00;C12N5/10;C12N5/20;C12N15/02;C12N15/09;C12N15/13;C12N15/85;C12P21/00;C12P21/06;C12P21/08;C12R1/91 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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