| 摘要 |
Polymer-biomolecule conjugates are prepared, generally in a site-specific or -selective manner, by a four- component condensation reaction. The method may be used to prepare conjugates having two polymer molecules attached at a single site on a biomolecule. The conjugates are typically water soluble and have beneficial pharmacological properties, such as reduced immunogenicity and increased circulation time. ® KIPO & WIPO 2007
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