发明名称 |
TRAIL RECEPTOR 2 POLYPEPTIDES AND ANTIBODIES |
摘要 |
<p>Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand ("TRAIL") Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.</p> |
申请公布号 |
CA2620470(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
CA20062620470 |
申请日期 |
2006.08.28 |
申请人 |
AMGEN, INC. |
发明人 |
GLINIAK, BRIAN;FENG, XIAO;YANG, XIAO-DONG;FOLTZ, IAN;FOSTER, STEPHEN;KETCHEM, RANDAL R.;WONG-MADDEN, SHARON;FITCH, ALISON |
分类号 |
C07K16/28;A61K39/00;C12N15/13 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|