TRANSGENIC NON-HUMAN ANIMAL CAPABLE OF PRODUCING HETEROGENOUS ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide a transgenic non-human animal capable of producing heterogenous antibodies.

SOLUTION: This is a mouse including a human heavy chain immunoglobulin variable region not rearranged where the variable region includes a plurality of human VHgene segments, a plurality of human D gene segments and a plurality of human JHgene segments and the B cells of the mouse express the chimeric antibody including the human immune globulin heavy chain variable region and the chimeric antibody including the mouse immune globulin heavy chain constant region.

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