发明名称 |
Method of manufacturing glimepiride and the respective intermediate |
摘要 |
A method of manufacturing glimepiride of formula I wherein trans-4-methylcyclohexylamine pivalate of formula VII is reacted, either directly or after conversion to trans-4-methylcyclohexylamine or to its another salt, with an alkyl [4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1 yl)carbonyl]amino)ethyl)phenyl]-sulfonyl carbamate of general formula IV wherein R is a C1-C5 alkyl, giving glimepiride of formula I. trans-4-Methylcyclohexylamine pivalate of formula VII.
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申请公布号 |
US2007054954(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
US20040546238 |
申请日期 |
2004.02.20 |
申请人 |
RADL STANISLAV;JARRAH KAMAL |
发明人 |
RADL STANISLAV;JARRAH KAMAL |
分类号 |
A61K31/4015;A61K;C07C211/35;C07D207/28;C07D207/38 |
主分类号 |
A61K31/4015 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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