发明名称 |
INJECTION FOR INTRAVENOUS DRIP |
摘要 |
<p>A high-content injection for intravenous drip which is prepared by adding an acidic pH regulator to an aqueous suspension containing 4-(N-(4-morpholin-4-yl)butyl)carbamoylmethyl)-5,6,7,8-tetrahydrophthalazin-1(2H)-one (Compound A) and dissolving it therein followed by, if necessary, adjusting the pH value by using a basic pH regulator. Because of being stable to light and heat, this injection is a highly useful preparation. It is preferable to adjust the pH value of the injection to 3 to 7. The concentration of the compound A is preferably from 50 mg/mL to 300 mg/mL and the viscosity of the injection is preferably from 1 mPa<SUP>.</SUP>s to 4 mPa<SUP>.</SUP>s.</p> |
申请公布号 |
WO2007026771(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
WO2006JP317123 |
申请日期 |
2006.08.30 |
申请人 |
ONO PHARMACEUTICAL CO., LTD.;TAKADA, AKIRA;YOSHIDA, MASATO |
发明人 |
TAKADA, AKIRA;YOSHIDA, MASATO |
分类号 |
C07D237/32;A61K9/08;A61K31/5377;A61K47/04;A61K47/12;A61K47/16;A61P1/04;A61P3/10;A61P7/00;A61P7/02;A61P9/10;A61P11/00;A61P13/12;A61P19/00;A61P19/02;A61P21/04;A61P25/00;A61P25/04;A61P25/16;A61P25/28;A61P27/02;A61P27/06;A61P29/00;A61P43/00 |
主分类号 |
C07D237/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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