3-3,5-DIOXO-4,5-DIHYDRO-3H-1,2,4TRIAZIN-2-YL-BENZAMIDE DERIVATIVES AS P2X7-INHIBIORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

摘要

The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.