发明名称 |
Compositions and methods for modulating immune responses |
摘要 |
The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
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申请公布号 |
US2007054360(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
US20060433276 |
申请日期 |
2006.05.12 |
申请人 |
GAO ZEREN;LEVIN STEVEN D;BILSBOROUGH JANINE;WEST JAMES W;BRANDT CAMERON S;RAMSDELL FREDERICK J;HOWARD EDWARD D;CHADWICK ERICK M |
发明人 |
GAO ZEREN;LEVIN STEVEN D.;BILSBOROUGH JANINE;WEST JAMES W.;BRANDT CAMERON S.;RAMSDELL FREDERICK J.;HOWARD EDWARD D.;CHADWICK ERICK M. |
分类号 |
C12P21/06;C07H21/04;C07K14/705;C07K16/30 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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