Methods for enzyme-mediated coupling of oligomers

摘要

The present invention is directed to a method for synthesizing sequence specific short and long chain length heteropolymers. More specifically, the method is directed to enzyme-mediated ligation of telechelic sequence specific oligomers to generate abiotic linked oligomers and concatenated synthetic oligomers. The invention also encompasses abiotic linked oligomers and abiotic concatenated oligomers comprising greater than 65 monomer units.