IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A GLCNACMAN3GLCNAC2 GLYCOFORM
摘要
Compositions and methods for producing compositions comprising immunoglobulins or immunoglobulin fragments having an N-linked glycosylation pattern consisting predominantly of the GlCNAcMan<SUB>3</SUB>GlcNAc<SUB>2</SUB> N-glycan structure are disclosed. The GlCNAcMan<SUB>3</SUB>GlcNAc<SUB>2</SUB> N-glycan structure effects an increase in binding to the Fc?Rip receptors and a decrease in binding to the Fc?RH receptors.
