RECOMBINANT ADENO-ASSOCIATED VIRUS CONTAINING VEGFR TRUNCATED CDNA AND GENE THERAPEUTIC AGENT FOR CANCER COMPRISING THE SAME

摘要

The present invention relates to a gene therapeutic agent using truncated cDNA of VEGF receptor protein (VEGFR) and adeno-associated virus(AVV) system, and more particularly, relates to a gene therapeutic agent specific to cancer, comprising a rAAV vector containing truncated cDNA of VEGFR-I, a rAAV vector containing truncated cDNA of VEGFR-2 and said vector. The gene therapeutic agent according to the present invention reduces the growth of tumors by inhibiting the expression and function of VEGF involved in angiogenesis necessary for the proliferation and metastasis of tumors. Thus, the inventive gene therapeutic agent can be effectively used to treat cancer at a gene level.