| 摘要 |
The invention relates to a method for preparing particles and, in particular, solid lipidic nanoparticles from a first liquid lipidic phase A comprising a lipid or a mixture of lipids, and from a second liquid phase B in which the lipid or the mixture of lipids of the first phase A is insoluble or slightly soluble. Said method uses a membrane reactor comprising a porous membrane, in which the second phase B circulates tangential to the membrane, and the first phase A held, before passing though the membrane, at a temperature greater than the melting point of the lipid of or the mixture of lipids, passes through the pores of the membrane in order to form droplets that have just met with the second phase B. The inventive method is characterized in that the second phase B is held at a temperature less than the melting temperature of the lipid or mixture of lipids constituting the first lipidic phase A so that the droplets of lipidic phase A that are formed solidify when coming into contact with the second phase B. |
