| 摘要 |
<p>An oligonucleotide analog containing a nucleoside analog represented by the following general formula (I): [Chemical formula 1] wherein R<SUB>1</SUB> to R<SUB>4</SUB> independently represent each H or a group selected from optionally substituted C<SUB>1-4</SUB> alkyl, halogen, OH, C<SUB>1-4</SUB> alkyl-OH, C<SUB>1-4</SUB> alkyl-O-C<SUB>1-4</SUB> alkyl, NH<SUB>2</SUB>, NO<SUB>2</SUB>, N(C<SUB>1-4</SUB> alkyl)<SUB>2</SUB>, O-C<SUB>1-4</SUB> alkyl, COOH, SH, SO<SUB>3</SUB>H, C<SUB>1-5</SUB> acyl, C<SUB>2-5</SUB> alkenyl, C<SUB>2-5</SUB> alkynyl, C<SUB>3-8</SUB> cycloalkyl, C<SUB>6-10</SUB> aryl and C<SUB>7-10</SUB> aralkyl; a method of detecting a target duplex DNA sequence in a sample by using the above oligonucleotide analog; a method of forming a triplex with a target duplex DNA; and a medicinal composition containing the above oligonucleotide analog.</p> |
