Canine tumor treatment method, pharmaceutical formulation applied thereto, and method of cryogenically preserving cells used therewith

摘要

A treatment for tumorous canines and a method of preparing, cultivating, and cryogenically preserving the pharmaceutical formulation used in the treatment. Canine lymphocytes are activated and expanded in the presence of a combination of anti-canine CD3 antibodies and interleukin-2 (IL-2) (preferably anti-canine CD3 antibodies and human interleukin-2 (human IL-2)) and administered to tumorous dogs. Following treatme-nt, the canine tumors were observed to be in regression while no serious side effects were noted.
Quality-of-life improvements were observed in the form of the animals' ability to walk increased distances and improved coat appearance.