ANTISENSE COMPOUNDS HAVING ENHANCED ANTI-MICRORNA ACTIVITY
摘要
<p>Antisense compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The antisense compounds exhibit enhanced anti- miRNA activity. Further provided are methods for enhancing the inhibitory activity of an antisense compound targeting a miRNA, comprising incorporating stability enhancing sugar modifications into the antisense compounds.</p>
申请公布号
WO2007027894(A2)
申请公布日期
2007.03.08
申请号
WO2006US34032
申请日期
2006.08.29
申请人
ISIS PHARMACEUTICALS, INC.;ESAU, CHRISTINE;SWAYZE, ERIC, E.