<p>Discloses is a process for producing a-D-glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-ß-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]- or 1-(dihydrogen phosphate) tetrasodium salt which is useful as an active ingredient of a pharmaceutical or an intermediate for the synthesis thereof, which is environment-friendly and excellent in safety, operationality and reproducibility. A process for producing a compound represented by the formula (I) comprising the steps of reacting a compound represented by the formula (VIII) with a palladium catalyst in the presence of a nucleopholic agent and treating the product with a sodium source. [Chemical formula 1] (VIII) (I)</p>
申请公布号
WO2007026675(A1)
申请公布日期
2007.03.08
申请号
WO2006JP316941
申请日期
2006.08.29
申请人
EISAI R & D MANAGEMENT CO., LTD.;TAGAMI, KATSUYA;SATO, KEIZO;MATSUO, KIMIHIRO;ABE, TAICHI;HAGA, TOYOKAZU