发明名称 5'-NUCLEOTIDASE-RESISTANT DERIVATIVE OF IMMUNOPOTENTIATING INOSINE-MONOPHOSPHATE AND USE THEREOF
摘要 <P>PROBLEM TO BE SOLVED: To provide a 5'-nucleotidase-resistant derivative of immunopotentiating inosine-mono-phosphoric acid that has more larger immunopotentiating activity, higher stability and resistance to 5'-nucleotidase. <P>SOLUTION: This invention relates to 5'-nucleotidase-resistant inosine-5'-monophosphoric acid and a method for producing the derivative and inosine-5'-monophosphoric acid is chemically changed to a compound represented by formula (I) (wherein R is selected from the group consisting of an alkyl, an alkoxy and secondary amino compound) and the biological activity of the inosine-5'-monophosphoric acid is allowed to retain in vivo. <P>COPYRIGHT: (C)2007,JPO&INPIT
申请公布号 JP2007056044(A) 申请公布日期 2007.03.08
申请号 JP20060330014 申请日期 2006.12.06
申请人 UNIV OF SOUTH FLORIDA 发明人 HADDEN JOHN W;GINER SOROLLA ALFREDO;MASIHI NOEL K
分类号 A61K45/00;A61K31/7076;A61P37/04;A61P43/00 主分类号 A61K45/00
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