发明名称 |
PREPARATION AND APPLICATIONS OF POLYMER-SUPPORTED HALOGENATED BENZOQUINONES AS OXIDATIVE AGENTS |
摘要 |
<p>This invention provides a general method for the synthesis of polymer-supported benzoquinones described by the following generic structure I: wherein: ., X, R<1>, R<2> and R<3> are described in the main text. The general concept of the method consists of the use of a halogenated starting material of the general structure II (Figure 1) which by an nucleophilic substitution reaction (NSR) or a palladium mediated coupling (PMC) is either directly loaded on a resin to afford IIIa (Path A) or transformed to intermediate IIIb (Path B) which is subsequently (with or without modification) loaded on a resin to afford once again IIIa. Deprotection and/or oxidation of IIIa, if needed, afford target solid-supported oxidants I The polymer-supported benzoquinones I are used for the oxidation of hydroquinones to quinones, for the oxidation of benzylic alcohols the aldehydes, for the removal of p-methoxybenzyl and related protective groups, for the dehydrogenation of tetrahydronaphthalene derivatives and for the dehydrogenation of steroid 4-en-3-ones. The polymer-supported reagent after its use is regenerated upon treatment with an oxidative agent.</p> |
申请公布号 |
EP1758850(A1) |
申请公布日期 |
2007.03.07 |
申请号 |
EP20040736534 |
申请日期 |
2004.06.10 |
申请人 |
COULADOUROS, ELIAS, ANDREA;STRONGILOS, ALEXANDROS |
发明人 |
ELIAS ANDREAS COULADOUROS;ALEXANDROS STRONGILOS |
分类号 |
C07C255/46;C07B33/00;C07C255/53;C07C255/54;C07C255/55;C07C255/57;C07C317/44;C07J75/00 |
主分类号 |
C07C255/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|