发明名称 |
A convenient method for the preparation of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine) |
摘要 |
<p>This is a novel method for production of no-carrier-added O -(2-[ 18 F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging. The preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R 1 is a protective group for the carboxyl functional group, R 2 is a protective group for the amino group, and R 3 acts as a leaving group. R 1 represents an arylalkyl group, R 2 represents a carboxyl group, and R 3 represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine. The final purification of the product is using a separation column, which is very convenient for automated synthesis. The invention uses the precursor with the chemical structures as in Formula 1.
Formula 1 : Synthesis precursors for O -(2-C 18 F]fluoroethyl)-L-Tyrosine.</p> |
申请公布号 |
EP1760056(A1) |
申请公布日期 |
2007.03.07 |
申请号 |
EP20050017898 |
申请日期 |
2005.08.17 |
申请人 |
INSTITUTE OF NUCLEAR ENERGY RESEARCH |
发明人 |
WANG, HSIN ER;WU, SHIH YAN;LIN, WUU JYH;CHEN, JENN TZONG;LO, AI REN;LEE, MING HSIN;CHANG, MAO HSIUNG |
分类号 |
C07B59/00;A61K51/04;C07C269/06;C07C271/22 |
主分类号 |
C07B59/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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