发明名称 |
INTERFERON ALPHA RECEPTOR 1 ANTIBODIES AND THEIR USES. |
摘要 |
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention. |
申请公布号 |
MX2007000023(A) |
申请公布日期 |
2007.03.07 |
申请号 |
MX20070000023 |
申请日期 |
2005.06.20 |
申请人 |
MEDAREX, INC. |
发明人 |
WITTE, ALISON;CARDARELLI, JOSEPHINE M.;SRINIVASAN, MOHAN |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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