Compounds and methods for modulating activation of NF-kappaB

摘要

Compositions and methods for modulating the activation of nuclear factor kappaB (NF-kappaB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IkappaBalpha and/or IkappaBbeta. Such compositions may be used for treating diseases associated with NF-kappaB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.